Download Ciba Foundation Symposium 191 - Non-Reproductive Actions of PDF

Popular clinicians and researchers from diversified disciplines speak about the fundamental phone and molecular biology of steroid motion and intercourse steroids' results at the frightened and immune structures. presents an built-in evaluate of the benefits and drawbacks of hormone substitute treatment.

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Oelkers: There are at least two components of this action. One is compatible with a nuclear effect, but the other one lasts only 5 min. What is the minimum time required for a change in cell function that is mediated by nuclear effects of steroid hormones? You mentioned that if rapid turnover proteins are involved it doesn’t have to be 1 h, but is it really as short as 5 min? Baulieu: Yes, you can observe signs of transcription activation within a couple of minutes with appropriate technology. Oelkers: Including changes in protein synthesis?

1,25-dihydroxyvitamin D3 leads to the activation of certain proteases or enzymes, whereas 24,25dihydroxyvitamin D3 has little or no effect (Boyan et al 1994). Oestrogen also has a specific effect: it has been shown that oestrogen elicits an increase in membrane fluidity by matrix vesicles from female rats, whereas oestrogen has no effect on matrix vesicles isolated from male rats (Gates et al 1994). So this is a very good system for examining totally non-genomic effects of hormones. Baulieu: When I reviewed the literature, I did not find a single example of a steroid being an allosteric ligand for an enzyme.

This might be explained by changes in the phosphorylation of the receptor or other factors interacting with the receptors. Antagonists could behave as agonists if something other than the ligand is helping convert the receptor to the structure that is normally achieved by the agonist. Parker: Would you assume, in that case, that the receptor is then bound to DNA? Beato: I can’t say this is what we have found, because if we raise cAMP levels in our cells, RU486 only reaches 10-15% of the normal agonistic activity.

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