By Wenkui Li, Jie Zhang, Francis L. S. Tse
Consolidates the data LC-MS bioanalytical scientists have to study small molecules and macromolecules
The box of bioanalysis has complex speedily, propelled by way of new ways for constructing bioanalytical equipment, new liquid chromatographic (LC) thoughts, and new mass spectrometric (MS) tools. in addition, there are a bunch of directions and rules designed to make sure the standard of bioanalytical results.
Presenting the easiest practices, experimental protocols, and the newest realizing of rules, this publication deals a finished evaluation of LC-MS bioanalysis of small molecules and macromolecules. It not just addresses the wishes of bioanalytical scientists engaged on regimen tasks, but in addition explores complex and rising applied sciences akin to high-resolution mass spectrometry and dried blood spot microsampling.
Handbook of LC-MS Bioanalysis beneficial properties contributions from a global staff of best bioanalytical scientists. Their contributions mirror a assessment of the most recent findings, practices, and laws in addition to their very own firsthand analytical laboratory event. The publication completely examines:
- Fundamentals of LC-MS bioanalysis in drug discovery, drug improvement, and healing drug monitoring
- The present figuring out of laws governing LC-MS bioanalysis
- Best practices and distinct technical directions for LC-MS bioanalysis process improvement, validation, and balance evaluation of analyte(s) of interest
- Experimental directions and protocols for quantitative LC-MS bioanalysis of not easy molecules, together with pro-drugs, acyl glucuronides, N-oxides, reactive compounds, and photosensitive and autooxidative compounds
With its concentrate on present bioanalytical perform, Handbook of LC-MS Bioanalysis permits bioanalytical scientists to advance and validate powerful LC-MS assay equipment, all in compliance with present rules and standards.