Download Burger's Medicinal Chemistry and Drug Discovery, Drug by Donald J. Abraham PDF

By Donald J. Abraham

This can be quantity 2: Drug Discovery and Drug Development, of Burger's Medicinal Chemistry and Drug Discovery, sixth version. This new quantity includes serious new chapters on Combinational Chemistry and a number of Parallel Synthesis, excessive Throughput Pharmacology, and Retrometabolism-Based Drug layout and concentrating on.

To buy the total 6 quantity set, please confer with ISBN 0-471-37032-0.

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Extra info for Burger's Medicinal Chemistry and Drug Discovery, Drug Discovery and Drug Development (Volume 2)

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31. H. Gao and J. Bajorath, J. Mol. Diversity, 4, 115 (1999). 32. H. Gao, C. Williams, P. Labute, and J. Bajorath, J. Chem. Znf. Comput. , 39, 164 (1999). 33. W. J. DunnIII, S. Wold, U. Edlund, S. Hellberg, and J. Gasteeger, Quant. -Act. , 3, 131 (1984). 34. J. Langley, J. , 1, 367 (1878). 35. P. Ehrlich, Klin. , 6, 299 (1897). 36. J. N. Langley, J. , 33,374 (1905). 37. M. Famulok, Curr. Opin. Struct. , 9, 324 (1999). 38. K. Y. Wang, S. Swaminathan, and P. H. Bolton, Biochemistry, 33, 7617 (1994).

17, 27 (1999). 54. A. R. Fersht, J. S. Shindler, and W . C. Tsui, Biochemistry, 19,5520 (1980). 55. P. R. Andrews, D. J. Craik, and J . L. Med. , 27,1648 (1984). 56. N. R. Draper and H . , John Wiley & Sons, New York, 1981. 57. Y . Martin in G. , Quantitative Drug Design, Marcel Dekker, New York, 1978, p. 167. 58. H. Kubinyi in R. Mannhold, P. KrogsgaardLarsen, and H. , QSAR: Hansch Analysis and Related Approaches, VCH, New York, 1993, p. 91. 59. R. Franke in W . Th. Nauta and R. F.

577 The enhanced activity of the "bridged" substituents was corrected by the indicator variable I. Note that triazines bearing the bridge --CH,OC,H,Y, moieties -CH,NHC,H,Y, and -CH,SC,H,Y had unusually high enzyme binding activity. Note that the -CH,NHC,H, bridge is present in the endogenous substrate, folic acid. The bilinear dependency on hydrophobicity of the substituents parallels that seen in the case of chicken liver DHFR. A similar QSAR was obtained for DHFR isolated from L1210 murine leukemia cells (209).

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