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Microbial Consortia or Symbiotic Systems . . . . . . . . . . . . . . . . . . . . . 61 62 64 65 65 66 66 67 67 68 References . . . . . . . . . . . . . . . . . . 68 1 Introduction Science and technology are international but their development can be affected by regional characteristics. This aspect is observed with development of biotechnology in Japan, which is characterized by unique contributions from applied microbiology and bioindustry.

This means that expansion of the targets of screening beyond antibiotics started early. , screening of agents inhibiting enzymes involved in diseases or symptoms. Pepstatin, a specific inhibitor of pepsin and other aspartic proteases, is an initial example [3]. It is evident that his idea has opened up an aspect of the current rational approach of targeted screening. Blasticidin S (1958) is the first antibiotic used in agriculture to prevent rice blast caused by a pathogenic fungus, Piricuralia oryzae.

Ruiz-Barba JL, Cathcart DP, Warner PJ, Jiménez-Diaz (1994) Appl Environ Microbiol 60:2059 68. Axelrod PE, Rella M, Schroth MN (1988) Appl Environ Microbiol 54:1222 69. Messenger AJM, Turner JM (1981) Soc Gen Microbiol Quart 8:263 70. Habte M, Alexander M (1977) Arch Microbiol 113:181 71. Singh BN (1942) Nature 149:168 72. Groscop JA, Brent MM (1964) Can J Microbiol 10:579 73. Imshenetskii AA (1974) Mikrobiologiya 43:185 74. Singh BN (1945) Br J Exp Pathol 26:316 75. Bird DF, Kalff J (1986) Science 231:493 76.

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