Download Bioadhesive drug delivery systems: fundamentals, novel by Edith Mathiowitz, Donald E. Chickering III, Claus-Michael PDF

By Edith Mathiowitz, Donald E. Chickering III, Claus-Michael Lehr

This valuable reference offers a accomplished evaluation of the fundamental equipment for characterizing bioadhesive fabrics and bettering motor vehicle focusing on and uptake-offering probabilities for reformulating current compounds to create new prescribed drugs at decrease improvement expenditures. Evaluates the original provider features of bioadhesive polymers and their strength to augment localization of introduced brokers, neighborhood bioavailability, and drug absorption and shipping! Written by means of over 50 foreign specialists and reflecting wide wisdom of either conventional bioadhesive concepts and novel medical purposes, Bioadhesive Drug supply structures ·discusses mechanical and chemical bonding, polymer-mucus interactions, the impression of floor power in bioadhesion, polymer hydration, and mucus rheology ·analyzes biochemical houses of mucus and glycoproteins, mobile adhesion molecules, and mobile interplay with - and third-dimensional surfaces ·covers microbalances and magnetic strength transducers, atomic strength microscopy, direct measurements of molecular point adhesions, and strategies to degree cell-cell interactions ·examines bioadhesive companies, diffusion or penetration enhancers, and lectin-targeted cars ·describes vaginal, nasal, buccal, ocular, and transdermal drug supply ·reviews bioadhesive interactions with the mucosal tissues of the attention and mouth, and people within the respiration, urinary, and gastrointestinal tracts ·explores problems with product improvement, scientific trying out, and creation ·and extra! Amply referenced with over 1400 bibliographic citations, and illustrated with greater than three hundred drawings, pictures, tables, and show equations, Bioadhesive Drug supply platforms serves as a legitimate foundation for innovation in bioadhesive structures and a very good creation to the topic. This detailed reference is perfect for pharmaceutical scientists and technologists; chemical, polymer, and plastics engineers; biochemists; actual, floor, and colloid chemists; biologists; and upper-level undergraduate and graduate scholars in those disciplines.

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H. einen Böschungswinkel von aufweist. Die wichtigsten Ursache sind zu geringe Teilchengrößen, geringe Dichte und ausgeprägte Kohäsivität. 2 EA: Verfügbare Maßnahmen Für den Fall 53° sind dagegen keine Maßnahmen verfügbar. Die Entwicklung muss daher abgebrochen werden.

Int J Pharm 114: 55-64 2-104. Sucker H, Fuchs P, Speiser P (1991) Pharmazeutische Technologie, 2. Aufl. Thieme, Stuttgart New York 2-105. Tan SB, Newton JM (1990) Powder flowability as an indication of capsule fllling performance. Int J Pharm 61: 145-155 2-106. Tobiska S, Kleinebudde P (2001) A simple method for evaluating the mixing effieiency of a new type of pan coater. Internat J Pharmaceuties 224: 141 2-107. Torres AI, Camacho MA (1994) Solid state interactions of two new antineoplastie drugs (mitonafide and amonafid) and common tablet exeipients in preformulation studies.

F. gH 20 m3 Luft 7 Vorgesehenes Granulierverfahren 8 Vorgesehene Tablettiermaschine bzw. Kapselfüllmaschine 9 Maschinengeschwindigkeit UpM (Tablettierrnaschinel 10 Vorgesehene Tablettenumhüllung Nr. 11 Produktionsstandort Ad 8 und 9: Falls das Granulat zu Tablenen weiterverarbeitet werden soll, müssen bei der Auswahl der Hilfsstoffe deren presstechnische Eigenschaften mitberücksichtigt werden. a. vom Tableniermaschinentyp (s. Kap. 4) und der Maschinengeschwindigkeit abhängen. (Für die Granulatcharakterisierung steht diesbezüglich hier nur die Maschine 1, d.

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