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By R W Foster (Eds.)

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Sample text

The activity of tyrosine hydroxylase is governed by the cytoplasmic concentration of NA, high NA concentration inhibiting enzyme activity. This is an example of feedback (product) inhibition. 27 Synthesis of NA Tyrosine hydroxylase exhibits some substrate specificity but is susceptible to inhibition by metirosine, a close structural analogue of tyrosine. It inhibits tyrosine hydroxylase and reduces catecholamine synthesis. It may be useful in phaeochromocytoma both preoperatively or as long-term therapy in inoperable cases.

Consequences of NA displacement: (1) less NA is available for release during neuroeffector transmission; (2) the displacing drug may be released in the place of NA during neuroeffector transmission (false transmission); (3) the response of the effector cell to the displacing drug may result from the pharmacological effects of displaced NA {see indirectly acting sympathomime­ tics, page 47). Methyldopa (cf. triethylcholine acting on cholinergic transmission, page 17) is a substrate for aromatic L-aminoacid decarboxylase and hence can be converted to The pharmacology of noradrenergic neuroeffector transmission 41 a-methyldopamine.

Discharge of one terminal bouton would not normally evoke an action potential in the postganglionic cell body. The effects of agonists at nicotinic cholinceptors on ganglionic transmission ACh, carbachol, nicotine These activate nicotinic cholinoceptors of the ganglion cell body and evoke depolarization. 20 The effects of agonists at nicotinic cholinoceptors on the electrical activity of an autonomie ganglion cell body The pharmacology of the cholinoceptors of ganglia 27 cross the threshold of excitability, the ganglion cell body generates an action potential.

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