By Tung-Hu Tsai
Discover new and rising functions for microdialysis in drug evaluation
Microdialysis is a hugely useful sampling software that may be utilized in vivo to degree unfastened, unbound analyte concentrations situated in interstitial and extracellular areas. This e-book explores the entire variety of medical functions for microdialysis, targeting its use in several organ and tissue structures for pharmacokinetic and pharmacodynamic reviews. Readers achieve an entire knowing of the underlying technological know-how of microdialysis, present concepts and practices, in addition to its many purposes in pharmaceutical research.
Applications of Microdialysis in Pharmaceutical technological know-how begins with an creation to easy rules after which covers analytical concerns, pharmacodynamic and pharmacokinetic stories, scientific points, and distinct purposes. themes include:
Role of microdialysis in drug improvement, together with an important sampling concerns and purposes for fearful approach diseases
Continuous dimension of glucose concentrations in diabetics
Applications for scientific review and simple study on organ platforms, together with tracking exogenous and endogenous compounds within the lungs
Pharmacokinetic and pharmacodynamic evaluate of anticancer drugs
Comparison of microdialysis with imaging ways to judge in vivo drug distribution
Special purposes of microdialysis in reviews of phone tradition assays, drug-drug interactions, and environmental monitoring
Throughout the ebook, readers will locate easy types that make clear advanced suggestions and easy-to-follow examples that advisor them via key functions in pharmaceutical learn. in brief, this e-book permits pharmaceutical researchers to take complete benefit of microdialysis ideas for the preclinical and medical evaluate of gear and masses extra.
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Additional info for Applications of Microdialysis in Pharmaceutical Science
Scandinavian Journal of Infectious Disease Supplementum, 14, 21–22. H. (1998). Pharmacokinetics of [18F]trovafloxacin in healthy human subjects studied with positron emission tomography. Antimicrobial Agents and Chemotherapy, 42, 2048–2054. , Ekblad, U. (2000). The transplacental transfer of the macrolide antibiotics erythromycin, roxithromycin and azithromycin. International Journal of Obstetrics and Gynaecology, 107, 770–775. , Müller, M. (2001). Microdialysis: a novel tool for clinical studies of anti-infective agents.
Pharmacokinetics of [18F]trovafloxacin in healthy human subjects studied with positron emission tomography. Antimicrobial Agents and Chemotherapy, 42, 2048–2054. , Ekblad, U. (2000). The transplacental transfer of the macrolide antibiotics erythromycin, roxithromycin and azithromycin. International Journal of Obstetrics and Gynaecology, 107, 770–775. , Müller, M. (2001). Microdialysis: a novel tool for clinical studies of anti-infective agents. European Journal of Clinical Pharmacology, 57, 211–219.
In this regard, Liu et al.  demonstrated that a PK–PD model based on unbound antibiotic concentrations at the site of infection, and a sigmoid Emax relationship, effectively described the antimicrobial efficacy of both cefpodoxime and cefixime. This approach offers more detailed information than the MIC does about the time course of antibacterial efficacy of antimicrobials under development . Therefore, in vivo PK–in vitro PD modeling of anti-infective drugs allows the simulation of different dosing strategies without needing a large sample of experimental subjects, therefore reducing the cost of drug development.