Download Absorption and Drug Development: Solubility, Permeability, by Alex Avdeef PDF

By Alex Avdeef

Repeatedly medications paintings effective while confirmed open air the physique, but if they're validated within the physique they fail. one of many significant purposes a drug fails is that it can't be take up via the physique in how to have the impact it used to be meant to have. Permeability, Solubility, Dissolution, and Charged country of Ionizable Molecules:

  • Helps drug discovery execs to do away with poorly absorbable molecules early within the drug discovery technique, which could shop drug businesses thousands of dollars.
  • Extensive tabulations, in appendix structure, of houses and constructions of approximately 2 hundred common drug molecules.

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Additional resources for Absorption and Drug Development: Solubility, Permeability, and Charge State

Example text

XÀ þ Hþ Ka2 ¼ ½XÀ Š½Hþ Š ½XHŠ ð3:4Þ Listed after the reactions are the corresponding equilibrium quotients. The law of mass action sets the concentration relations of the reactants and products in a reversible chemical reaction. The negative log (logarithm, base 10) of the quotients in Eqs. 8) indicate that when the concentration of the free acid, HA (or conjugate acid, BHþ), equals that of the conjugate base, AÀ (or free base, B), the pH has the special designation, pKa . If the pH is two units lower than the pKa for an acid, Eq.

128 265 162, p. 109 358 362 265 265 —b 474 162, p. 2 162, p. 8 162, p. 10 358 161, p. 1 41 (Continued ) Compound pKa ta ð CÞ IðMÞ Ref. 17 162, p. 121 509 162, p. 15 —b 149 385 —b 385 Verapamil Warfarin Xipamide Zidovudine Zopiclone Temperature 25 C, unless otherwise noted. pION. c Sirius Analytical Instruments. a b CHAPTER 4 PARTITIONING INTO OCTANOL In all other sections of this book, we use the term Kp to represent the partition coefficient and Kd , the apparent partition coefficient. These terms were chosen to avoid symbol conflict when discussing permeability and diffusivity.

Extensions of the Born electrostatic model, drawing on Bjerrum’s theory of ion association [223], were introduced by Yasuda [194] and Shedlovsky [201]. It was recognized that equilibrium quotients in mixed solvents of varying proportions ought explicitly to incorporate the concentration of water, since constancy in water activity cannot be expected in cosolvent mixtures. It was thus proposed that the plot of psKa þ log [H2O] versus 1/E should produce a straight line for solutions with dielectric constant E, > 50, which for methanol at 25 C means Rw < 60 wt%.

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